Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men |
| |
Authors: | Jean?Y?Tang Neeta?Parimi Angela?Wu W?John Boscardin James?M?Shikany Mary-Margaret?Chren Steven?R?Cummings Jr" target="_blank">Ervin?H?EpsteinJr Douglas?C?Bauer for the Osteoporotic Fractures in Men Study Group |
| |
Institution: | (1) Children’s Hospital of Oakland Research Institute, Oakland, USA;(2) Stanford University School of Medicine, Pavilion C, Room C-232, 450 Broadway Street, Redwood City, CA 94063-5334, USA;(3) California Pacific Medical Center Research Institute, San Francisco, USA;(4) University of California San Francisco, San Francisco, USA;(5) University of Alabama at Birmingham, Birmingham, USA |
| |
Abstract: | To determine the relationship between 25(OH) vitamin D levels and non-melanoma skin cancer (NMSC), we performed a nested case–control
study in ambulatory, elderly men enrolled in the Osteoporotic Fractures in Men (MrOS) Study. Health habit and medical history,
including self-reported history of NMSC were recorded and 25(OH)D levels were measured on serum collected at baseline from
a random sample of Caucasian MrOS subjects. Mean age (73 ± 5), BMI, daily vitamin D and calcium intake were similar in the
men with (n = 178) and without NMSC (n = 930), but higher levels of 25(OH)D were associated with a decreased risk of having a history of NMSC (P
trend
= 0.04). Men in the highest quintile of 25(OH)D (>30 ng/mL) had 47% lower odds of NMSC (95% CI: 0.30–0.93, p = 0.026) compared to those in the lowest quintile. Our results suggest that a diagnosis of NMSC is not a surrogate for adequate
25(OH)D levels or increased UV exposure, and high 25(OH)D levels may be associated with a reduced risk of NMSC. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|