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复发性流产患者外周血T淋巴细胞亚群及CD4^+辅助性T淋巴细胞亚型的变化
引用本文:Mao L,Yang P,Yan Y. 复发性流产患者外周血T淋巴细胞亚群及CD4^+辅助性T淋巴细胞亚型的变化[J]. 中华妇产科杂志, 2000, 35(12): 722-723
作者姓名:Mao L  Yang P  Yan Y
作者单位:的工作人员,既往无不良孕产史,有1胎以上正常足月分娩史,平均年龄26.5岁(23~36岁),分离外周血PBMC的方法同上。;二、 方法;1. 试剂:ELISPOT试剂盒、莫能菌素、依诺霉素、十四酰佛波酰乙酯(PMA)由北京中日友好医院临床检验研究所提供,淋巴细胞分离液由中国医学科学院血液病研究所提供。
摘    要:

关 键 词:习惯性流产 T淋巴细胞亚群 Th细胞亚型
修稿时间:1999-10-21

Changes of T lymphocyte and CD4+ T helper subsets in peripheral blood from women with unexplained recurrent spontaneous abortion
Mao L,Yang P,Yan Y. Changes of T lymphocyte and CD4+ T helper subsets in peripheral blood from women with unexplained recurrent spontaneous abortion[J]. Chinese Journal of Obstetrics and Gynecology, 2000, 35(12): 722-723
Authors:Mao L  Yang P  Yan Y
Affiliation:Department of Immunology, Tainjin Medical University, Tianjin 300070, China.
Abstract:OBJECTIVE: To investigate the relationship between occurrence of unexplained recurrent spontaneous abortion(URSA) and immune function of T lymphocytes. METHODS: T lymphocyte subsets and CD4+ T helper subsets (including T helper 1 and T helper 2 cells) in peripheral blood from 30 cases with URSA and 24 healthy women (controls) were detected by enzyme-linked immunospot assay (ELISPOT). RESULTS: The percentage of CD4+ positive T lymphocytes in URSA group was higher than that in the controls (60% vs 45%, P < 0.05). Compared with the normal group, the percentage of Th1 cells increased (26% vs 14%, P < 0.01) but the percentage of Th2 cells decreased (7% vs 20%, P < 0.05), the ratio of Th1 to Th2 increased (3.80 vs 0.73, P < 0.01) in the URSA group. CONCLUSIONS: The occurrence of URSA might be associated with proliferation of the CD4+ positive T cells and enhancement of cellular immune function mediated by Th1 cells.
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