凉血解毒法治疗原发性免疫性血小板减少症的临床研究

目的观察凉血解毒中药治疗原发性免疫性血小板减少症（ITP）的临床疗效。方法将64例ITP患者随机分为两组,治疗组予地黄止血胶囊与凉血解毒中草药煎剂升板汤口服;对照组予泼尼松口服。两组均以1个月为1个疗程。观察比较两组临床疗效、治疗前后血小板计数、出血症状及不良反应情况。结果治疗1个月时,治疗组总有效率为87.5%,对照组为76.7%,总有效率两组比较无统计学意义（P〉0.05）。治疗2个月后,治疗组出血症状改善明显优于对照组（P〈0.01）。治疗3个月后,治疗组平均血小板数量显著高于对照组（P〈0.01）。治疗组不良反应发生率9.4%,对照组不良反应发生率34.4%。两组不良反应发生率比较,差异有统计学意义（P〈0.05）。结论凉血解毒中药治疗ITP近期疗效与泼尼松相当,但不良反应发生率显著低于泼尼松。

Clinical Research of Primary Thrombocytopenic Purpura Treated with the Therapy for Cooling Blood and Detoxification

Objective To observe the clinical efficacy on primary immune thrombocytopenia（ITP）treated with Chinese medicine for cooling blood and detoxification.Methods 64 cases of ITP were randomized into two groups.In a treatment group,dihuang zhixue capsules and sheng ban tang,herbal decoction for cooling blood and detoxification were prescribed for oral administration.In a control group,prednisone was prescribed for oral administration.The duration of treatment was 1 month for both groups.The clinical efficacy,the platelet counts before and after treatment,hemorrhagic symptoms and adverse reaction were observed and compared between two groups.Results In the treatment of 1 month,the total effective rate was 87.5% in the treatment group and was 76.7% in the control group,without significant difference in statistical comparison（P0.05）.The improvement in hemorrhagic symptom was superior in the treatment group as compared with the control group（P0.01）.In the treatment of 3 months,the mean platelet count in the treatment group was higher significantly than that in prednisone control group（P0.01）.The incidence of adverse reaction was 9.4% in the treatment group and was 34.4% in the control group,presenting the statistical significant difference in comparison（P0.05）.Conclusion Chinese medicine for cooling blood and detoxification achieves the same short-term efficacy on ITP as prednisone,but its incidence of adverse reaction is lower significantly than prednisone.