| Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes |
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| 作者姓名： | Mi-Young Song Ui-Jin Bae Bong-Hee Lee Kang-Beom Kwon Eun-A Seo Sung-Joo Park Min-Sun Kim Ho-Joon Song Keun-Sang Kwon Jin-Woo Park Do-Gon Ryu Byung-Hyun Park |
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| 作者单位： | Department of Biochemistry Medical School and Diabetes Research Center Chonbuk National University Jeonju Jeonbuk 561-756 South Korea Department of Physiology School of Oriental Medicine Wonkwang University Iksan Jeonbuk 570-749 Department of Food and Nutrition School of Human Environmental Science Department of Herbology Department of Preventive Medicine Medical School |
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| 基金项目： | Supported by Grant from the Ministry of Science and Technology/Korea Science and Engineering Foundation through the Diabetes Research Center at Chonbuk National University, R13-2008-005-0000-0;; a Research Fund of Chonbuk National University in 2009 (to Park BH) |
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| 摘 要： | AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity. RESULTS: Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was conf irmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were c...
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| 关 键 词： | Nardostachys jatamansi Cytokines Streptozotocin Pancreatic β cells Nuclear factor κB Nitric oxide Diabetes mellitus |
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