5-氯-3-（2-噻吩甲酰）-1-甲酰胺-2-羟基吲哚钠盐的合成

目的：合成具抗炎活性的5－氯－3（2－噻吩甲酰）－1－甲酰胺－2－羟基吲哚钠盐。方法：以对氯苯胺为起始原料，经四步反应制得关键中间体5－氯－2－羟基吲哚，收率75％，然后与三氯乙酰异腈酸酯和2－噻吩甲酰氯反应，最后经NaHCO3处理，制得标题化合物。结果：总有收率可达45％以上，标题化合物经红外光谱、核磁共振谱、质谱及元素分析确证了结构，结论：该实验方法条件温和，操作简单、收率高，适合大规模合成。

SYNTHESIS OF SODIUM SALT OF 5-CHLORO-3-(2-THENOYL)-2-OXINDOLE-1-CARBOXYAMIDE

OBJECTIVE:A facile synthesis of sodium salt of 5 chloro 3 (2 thenoyl) 2 oxindole 1 carboxyamide from common 4 chloroaniline is described.METHODS:The key intermediate 5 chloro 2 oxindole(4) is prepared successfully in 75% yield from 4 chloroaniline in four steps, and converted by reaction with trichloroacetyl isocyanate into the N trichloroacetyl 5 chloro 2 oxindole 1 carboxyamide,and followed hydrolysis, then 5 chloro 2 oxindole 1 carboxyamide(5) is obtained. Condensation of (5) with 2 thenoyl chloride gives 5 chloro 3 (2 thenoyl) 2 oxindole carboxyamide(6). The title compound is obtained by treating(6) with NaHCO 3.RESULTS:The title compound is prepared successfully over 45% yield. The structure is characterized by elementary analysis,IR,MS, 1H NMR,H H COSY, 13 C NMR ,DEPT and HMQC. CONCLUSION:The method is simple and applicable to large scale preparation