Alcohol-induced rosacea flushing blocked by naloxone |
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| Authors: | JE BERNSTEIN K SOLTANI |
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| Institution: | The Department of Medicine, Section of Dermatology, The University of Chicago Pritzker School of Medicine, Chicago, Illinois |
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| Abstract: | We evaluated the roles of endogenous opioid peptides and histamine in the pathophysiology of alcohol-induced facial flushing in rosacea. Non-diabetic patients with rosacea ingested 360 ml of 6% ethanol after receiving either subcutaneous naloxone hydrochloride or oral chloropheniramine maleate. Only pretreatment with naloxone blocked the alcohol-induced rosacea flushing (AIRF), suggesting an active role of endogenous enkephalin and/or endorphin in this vascular reactivity. In this respect, AIRF is similar to chlorpropamide alcohol flushing and menopausal flushing. |
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