氟伐他汀对高脂血症患者的血脂及细胞粘附分子的影响

为研究氟伐他汀对高脂血症患者的降脂作用及对细胞粘附分子的影响。选择高脂血症患者 5 8例 (男性 35例 ,女性 2 3例 ) ,予氟伐他汀 4 0mg口服 ,每晚一次 ,一周后改为 2 0mg ,每晚一次 ,疗程 6～ 8周。分别观测治疗前后血脂及细胞粘附分子的情况。结果发现 ,治疗后患者总胆固醇、甘油三酯、低密度脂蛋白、血清可溶性细胞间粘附分子 1和血清可溶性血管细胞粘附分子 1明显降低 (P <0 .0 5 ) ,而高密度脂蛋白升高不明显。此结果提示 ,氟伐他汀不但能降低总胆固醇、甘油三酯及低密度脂蛋白水平 ,而且能降低血清可溶性细胞间粘附分子 1和血清可溶性血管细胞粘附分子 1浓度。

The Effect of Fluvastatin on Serum Lipid and Adhesive Molecules Levels of Patients with Hyperlipidemia

Aim To study the effect of fluvastatin on serum l ip id and adhesive molecules. Methods 58 patients wit h hyperlipidemia (male 35, female 23) received fluvastatin 40 mg, po, for one week and then the dosage were reduced to 20 mg night. The therpeutic course wa s 6 8 week. Results After treatment the average lev els of serum TC, TG, LDL, soluble intercellular adhesion molecule (sICAM) 1 and soluble vascular cell adhesion molecule (sVCAM) 1 were lowered significantly (P<0.05), but HDL was not significantly elevated. Conclusion Fluvastatin not only decreased TC,TG and LDL, but als o decreased sICAM 1 and sVCAM 1 concentration.