| 大鼠急性氧化乐果中毒呼吸衰竭与救治 |
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| 引用本文： | 邱泽武,赵德禄,史寅奎,黄韶清,刘艳琴.大鼠急性氧化乐果中毒呼吸衰竭与救治[J].中国急救医学,2001,21(2):71-72. |
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| 作者姓名： | 邱泽武 赵德禄 史寅奎 黄韶清 刘艳琴 |
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| 作者单位： | 1. 军事医学科学院附属医院急诊科，北京 100039
2. 军事医学科学院毒物药物研究所 |
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| 摘 要： | 目的 探讨氧化乐果中毒致呼吸肌麻痹的形成过程，寻找防治呼吸肌麻痹的合理方案。方法 所有实验大鼠均给予同等程度(2LD
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| 关 键 词： | 氧化乐果 中毒 呼吸肌麻痹 阿托品 氯磷定 |
| 文章编号： | 1002-1949(2001)02-0071-02 |
| 修稿时间： | 2000年6月20日 |
Effects of acute
omethomate poisoning on rats in respiratory failure with treatment |
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| QIU Ze-wu ,ZHAO De-lu ,SHI Yin-kui ,et al..Effects of acute
omethomate poisoning on rats in respiratory failure with treatment[J].Chinese Journal of Critical Care Medicine,2001,21(2):71-72. |
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| Authors: | QIU Ze-wu ZHAO De-lu SHI Yin-kui |
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| Institution: | QIU Ze-wu 1,ZHAO De-lu 2,SHI Yin-kui 1,et al. 1 Department of Emergence,Beijing 307th Hospital,Beijing 100039,China [ |
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| Abstract: | Objective The study was designed to examine the mechanism of respiratory muscle paralysis by acute omethomate poisoning. Methods Rats were administered in vivo with same doses of omethomate(2LD 50 ) and rats were treated with atropine or atropine plus PAM-CI. The function of isolated rats phrenic diaphragm was observed by MS-302 analyses instrument in physiology and pharmacology. Results In atropine group the function of isolated rats phrenic diaphragm was significantly less than that in control group ( P< 0.01). In atropine plus PAM-CI group the function of isolated rats phrenic diaphragm was similar to control group. Conclusion The reason of respiratory muscle paralysis may be related to the unreasonable treatment between atropine and PAM-CI. |
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| Keywords: | Omethomate Poisoning Respiratory muscle paralyis Atropine PAM-CI |
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