六味地黄汤对衰老加血瘀模型大鼠血脂和纤溶活性的影响 |
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作者姓名: | 卞慧敏 龚婕宁 魏凯峰 刘学风 俞晶华 |
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作者单位: | 南京中医药大学植物药深加工工程研究中心 江苏南京210029(卞慧敏, 俞晶华), 南京中医药大学基础医学院 江苏南京210029(龚婕宁, 魏凯峰, 刘学风) |
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基金项目: | 中国科学院资助项目;江苏省教育厅自然科学基金;江苏省中医药局科研项目 |
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摘 要: | 目的利用衰老加血瘀模型大鼠研究六味地黄汤及其配伍对血脂和纤溶活性的影响。方法本实验利用衰老加血瘀动物模型,观察了六味地黄汤及其配伍对模型大鼠体外血栓形成、血清脂质、纤维蛋白原(Fg)、组织纤溶酶原激活物(t-PA)和纤溶酶原激活抑制物(PAI)的影响。结果六味地黄汤全方能抑制模型大鼠体外血栓形成,降低血脂、Fg含量,减少内皮细胞分泌PAI,增加t-PA的水平。结论六味地黄汤通过改善模型大鼠内皮细胞分泌功能,调节血脂和纤溶系统,达到抑制血栓形成的目的。
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关 键 词: | 六味地黄汤 血栓形成 血脂 衰老加血瘀模型 纤维蛋白原 组织纤溶酶原激活物 纤溶酶原激活抑制剂 |
文章编号: | 1000-5005(2006)01-0028-03 |
收稿时间: | 2005-09-12 |
修稿时间: | 2005-10-08 |
Effect of Liuwei Dihuang Decoction on Blood Lipid and Fiber Dissolution Activity of Aging Rat Models with Blood Stasis |
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Authors: | BIAN Hui-min GONG Jie-ning WEI Kai-feng LIU Xue-feng YU Jing-hua |
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Institution: | 1. Plant Medicine Refining Center of Nanjing University of Traditional Chinese Medicine. Nanjing , Jiangsu, 210029, China;2. Basic Medi cal College of , Nanjing University of Traditional Chinese MedMne, Nanjing, Jiangsu, 210029, China |
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Abstract: | OBJECTIVE To investigate into the effect of Liuwei Dihuang Decoction and its drug combination on blood lipid and fiber dissolution activity based on experiments on aging rat models with blood stasis. METHOD Using aging rat models with blood stasis,the authors made observations on the effect of Liuwei Zihuang Decoction and its drug combination on rat in vitro thrombosis,serum lipid,brinase,tissue plasminogen activator(t-PA) and plasminogen activator inhibitor(PAI). RESULT Liuwei Dihuang Decoction could inhibit rat in vitro embolism,reduce blood lipid and brinase content,decrease PAI secretion and increase the level of t-PA.CONCLUSION By regulating the secretion function of the endothelium cell of the rat models,Liuwei Dihuang Decoction can regulate blood lipid and the fibrinolytic system,thus inhibiting the formation of thrombus. |
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Keywords: | Liuwei Dihuang Decoction thrombosis blood lipid aging rat model with blood stasis brinase tissue plasminogen activator plasminogen activator inhibitor |
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