| 姜黄素对小鼠CFU—GM及WEHI—3B细胞增殖的影响 |
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| 引用本文： | 蒋德昭,谢祁阳.姜黄素对小鼠CFU—GM及WEHI—3B细胞增殖的影响[J].湖南医科大学学报,2000,25(3):216-218. |
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| 作者姓名： | 蒋德昭 谢祁阳 |
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| 摘 要： | 用体外半固体集落培养方法，观察不同浓度姜黄素对ＢＡＬＢ／ｃ小鼠骨髓粒－巨噬系祖细胞及骨髓单核系白血病干细胞增殖的影响。结果显示：姜黄素呈剂量依赖性抑制ＣＦＵ－ＧＭ和ＷＥＨＩ－３Ｂ细胞增殖，其半抑制剂量分别为１．０３６＊１０＾－５ｍｏｌ．Ｌ＾－１和１．２２０＊１０＾－６ｍｏｌ．Ｌ＾－１。表明姜黄素对ＷＥＨＩ－３Ｂ白血病细胞的抑制作用强于对ＣＦＵ－ＧＭ的作用。
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| 关 键 词： | 姜黄素 粒－巨噬系祖细胞 WEHI－3B细胞系 白血病 |
Effect of curcumin on the proliferation of murine CFU-GM and WEHI-3B cells] |
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| D Z Jiang,Q Y Xie,Q R Wang.Effect of curcumin on the proliferation of murine CFU-GM and WEHI-3B cells][J].Bulletin of Hunan Medical University,2000,25(3):216-218. |
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| Authors: | D Z Jiang Q Y Xie Q R Wang |
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| Institution: | Research Laboratory of Blood Physiology, Hunan Medical University, Changsha 410078. |
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| Abstract: | OBJECTIVE: To evaluate the effect of curcumin on the proliferation of hematopoietic progenitor cells or leukemic stem cells. METHODS: Mouse bone marrow cells (colony forming unit-granulocyte and macrophage, CFU-GM) and WEHI-3B cells were observed using the colony assays. RESULTS: The curcumin significantly inhibited the proliferation of both CFU-GM and WEHI-3B cells in a dose-dependent manner ranging from 10(-8) to 10(-4) mol.L-1; their IC50S were 1.036 x 10(-5) mol.L-1 and 1.220 x 10(-6) mol.L-1 of curcumin respectively. CONCLUSION: The proliferation of murine CFU-GM and WEHI-3B cells can be suppressed by curcumin. The inhibitory effect of curcumin on the proliferation of WEHI-3B cells is stronger than that of CFU-GM. |
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