乌拉地尔与酚妥拉明治疗重度子痫前期临床对比研究

目的：探讨乌拉地尔与酚妥拉明对重度子痫前期的治疗作用。方法：将72例重度子痫前期患者分成两组,乌拉地尔组35例和酚妥拉明组37例,乌拉地尔组以5%葡萄糖加入乌拉地尔100mg静脉滴注,根据血压调整滴数。酚妥拉明组以5%葡萄糖500ml＋酚妥拉明20mg静脉滴注,根据血压调整滴数。结果：用药15min乌拉地尔组收缩压舒张压开始明显下降,用药15、30、60、120min与用药前比较差异有显著性（P〈0.05）。酚妥拉明组用药后15、30min收缩压下降没有显著性,用药60min时收缩压及用药120min后舒张压较用药前下降,差异有显著性（P〈0.05）。两组分娩方式、围生新生儿病死率、围生新生儿窒息率比较无显著性差异（P〉0.05）。结论：乌拉地尔可以迅速控制重度子痫前期患者血压,防止并发症,有利于延长孕周,提高围生儿存活率。

Clinical comparison between Urapidil and Phentolamine in treating severe preeclampsia

Objective: To study the curative effects of Urapidil and Phentolamine on severe preeclampsia.Methods: 72 patients with severe preeclampsia were divided into two groups.One group with 35 cases treated by Urapidil and the other group with 37 cases treated by Phentolamine.For Urapidil group,100 mg intravenous drip of Urapidil was added to 5% glucose;the drop for patients was adjusted based on blood pressure.For Phentolamine group,20mg intravenous drip of Phentolamine was mixed with 500ml 5% glucose;the drop for patients was regulated according to blood pressure.Results: 15 minutes later,both systolic blood pressure and diastolic blood pressure in Urapidil group began to fall evidently.The blood pressure after 15 minutes,30 minutes,60 minutes,and 120 minutes was quite different by comparison to that of pre-treatment respectively(P<0.05).The systolic blood pressure of Phentolamine didn't decrease remarkably 15 and 30 minutes after treatment;the systolic blood pressure at 60 minutes and diastolic blood pressure 120 minutes later reduced comparing with that of pretreatment,difference for blood pressure between pre-treatment and after treatment is distinct(P<0.05).Regarding delivery mode of two groups,the comparison between death rate of perinatal infant and asphyxia rate of perinatal infant was as near as makes no difference(P>0.05).Conclusion: Urapidil can control blood pressure of patient with severe preeclampsia as quickly as possibly,prevent occurrence of complication,help prolong pregnant-week,and improve fraction surviving of perinatal infants.