Immunogenic Deposition and Destruction of Glomerulus in IgA Nephritis |
| |
Authors: | Hidekazu Shigematsu Yutaka Kobayashi Sumio Tateno Yoshiyuki Hiki Sadahito Kuwao |
| |
Affiliation: | Department of Pathology, Shinshu University School of Medicine, Matsumoto.;Departments of Medicine School of Medicine, Kitasato University, Sagami-hara;Pathology, School of Medicine, Kitasato University, Sagami-hara. |
| |
Abstract: | The correlation between glomerular immune deposition and histological alteration was studied in serial paraffin sections of kidney biopsy specimens from patients with IgA nephritis using the peroxidase antiperoxidase (PAP) method. IgA deposition was detected in preserved glomerular extracellular matrix or in newly formed interposed matrix along the capillary loops (mesangial interposition). On the other hand, deposition of IgA was scanty or absent in the distorted extracellular matrix where severe exudative inflammation or extracapillary escape of exudates was occurring segmentally. Ultrastructurally such extracellular matricial destruction was expressed as splitting or thinning of the lamina densa, as well as mesangial edema, reticulation or mesangiolysis of the axial matrix. Therefore it appears that at least two types of change in the extracellular matrix are induced by IgA immune complexes in IgA nephritis; immunogenic deposition and destruction. |
| |
Keywords: | IgA nephritis Extracellular matrix Deposition Mesangiolysis Splitting |
|
|