Presence of autoantibodies against small nuclear ribonucleoprotein epitopes in Chagas' patients' sera |
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| Authors: | M. Bach-Elias D. Bahia D. C. Teixeira R. M. B. Cicarelli |
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| Affiliation: | (1) CID-CSIC. c/Jorge Girona Salgado 18-26, E-08034 Barcelona, Spain e-mail: mbebmc@cid.csic.es, Tel.: 34-3-4006134, Fax: 34-3-2045904, ES;(2) UNESP, Faculdade de Ciencias Farmaceuticas, Araraquara, SP, Brazil, BR |
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| Abstract: | We investigated the possibility that Chagas' patients develop an autoimmune response to human UsnRNPs (small nuclear ribonucleoprotein) or Sm epitopes. Using purified human UsnRNPs, we detected anti-human UsnRNPs antibodies in sera from patients suffering from Chagas' disease. The antibodies were also detected using peptide enzyme-linked immunosorbent assays containing the Sm-motif 1 domain. The latter technique showed that 61% (31/51) of the Chagas' patients' sera contained antibodies against Sm-motif 1. The detection of anti-UsnRNPs autoantibodies in Chagas' patients' sera strongly encourages further studies using animal models to determine how these autoantibodies appear. Received: 4 April 1998 / Accepted: 13 May 1998 |
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