青岛市部分患者与献血者人群Rh表型及单体型频率分布特征分析

目的 了解本院患者人群与本地献血者人群Rh血型系统抗原表型及单体型和不规则抗体等的分布特征,以确保临床安全、有效输血及提高临床用血合理性与科学性.方法 选取本院2015年10月～2020年3月住院患者和在此期间青岛市中心血站发往本院的献血者血液共113 326人(份)的Rh抗原分型和不规则抗体检测结果数据,回顾性分析并...

The distribution characteristics of Rh phenotype and haplotype frequency in Qingdao:An analysis based on some patients and local blood donors

Objective To investigate the distribution characteristics of Rh blood group antigen phenotypes, haplotypes and irregular antibodies between patients in our hospital and local blood donors, so as to ensure safe and effective blood transfusion and improve the rationality and scientificity of clinical blood transfusion. Methods A total of 113 326 blood samples, from hospitalized patients in our hospital and local blood donors from October 2015 to March 2020, were subjected to Rh antigen typing and irregular antibody detection. The frequency of Rh phenotypes, haplotypes, and irregular antibodies were retrospectively analyzed and calculated. Chi square test was used to compare the data among different population groups. Rh antigen typing and irregular antibody detection were completed using the automatic blood group analyzer. Results The prevalence of negative RhD was 0.36%(408/113 326).The most prevalent Rh phenotype was DCCee [40.69%(46 112/113 326)] followed by DCcEe[36.82%(41 727/113 326)]. Anti-E was the most common irregular antibody, accounting for [0.26%(295/113 326)], and DCe[62.51%(70 840/113 326)] was the most common haplotype. The most common Rh phenotypes and haplotypes in Caucasians in Germany, North Indian and North African were DCcee, DCCee and Dccee, while DCe, DCe and Dce, respectively. Conclusion The distribution characteristics of Rh phenotypes, haplotypes and irregular antibodies of patients in our hospital and local blood donors were in line with the distribution characteristics of the population in northern China. Corresponding plans concerning blood storage and collection, as well as the establishment of Rh blood type registry should be carried to effectively ensure the safety, rationality and accuracy of clinical blood transfusion.