温州地区女性人乳头瘤病毒的感染情况及亚型分布特征分析

目的:了解本地区女性HPV的感染情况及型别分布,以助于HPV疫苗的研制和应用。方法:采用快速分子导流杂交分型技术对4314例女性HPV的感染情况及型别分布进行分析。结果:HPV感染阳性率为41.68%(1798/4314)。10组年龄组中筛查人群以31岁～50岁的妇女为主,占72.02%(3107/4314);HPV阳性率以21岁～25岁(56.86%)及≥60岁(64.39%)的年龄组较高。各年龄组均以单重感染为主,其次为双重感染。在单重感染下,高危亚型均以HPV16、52、58为主,其次为HPV18、33;低危亚型以HPV6、11为主;常见亚型以HPV53、cp8304(81)为主。结论:温州地区女性HPV感染以单重感染为主,高危亚型优势型别为HPV16、52、58,低危亚型优势型别为HPV6、11,常见亚型优势型别为HPV53、cp8304(81)。

Infection and genotype distribution of human papilloma virus(HPV) in female in Wenzhou

Objective:To investigate the infection and genotype distribution of human papilloma virus in female in Wenzhou for development and application of HPV vaccine.Methods: The cervical samples of 4314 women were detected with flow-through hybridization and gene chip on HPV subtype was also analyzed.Results: The HPV positive rate was 41.68%(1798/4314).Screened women were mainly between 31 to 50 years old in 10 age groups,accounting for 72.02%.The higher HPV positive rates were occupied by 21 to 25 years old group(56.86%) and ≥60 years old group(64.39%).The common HPV infection in 10 age groups was mainly single infection,secondly double infection.In single HPV infection,HPV16,HPV52 and HPV58 were the most frequent high risk subtypes,HPV18 and HPV33 were the secondly frequent high risk subtypes;HPV6 and HPV11 were the most frequent low risk subtypes;HPV53 and HPV cp8304(81) were the most frequent common subtypes.Conclusion: The most common HPV infection was single infection in Wenzhou.The predominate high risk subtype was HPV16,HPV52 and HPV58,the predominate low risk subtype was HPV6 and HPV11,the predominate common subtype was HPV53 and HPV cp8304(81).