MMP-9和IL-12在妊娠期高血压疾病胎盘上的表达

目的通过分析子痫前期患者与正常晚孕妇女胎盘组织中基质金属蛋白酶一9和白介素12的表达,探讨其在妊娠期高血压疾病(PIN)中的作用及两者的相关性。方法采用免疫组织化学染色法测定MMP-9和IL-12在28例妊娠期高血压疾病患者(10例为子痫前期轻度;18例为子痫前期重度)和10例正常妊娠患者胎盘上的表达。结果妊娠期高血压疾病组胎盘MMP-9的表达明显低于正常妊娠组(P<0.01);妊娠高血压疾病组胎盘IL-12的表达明显高于正常妊娠组(P>0.01),随病情加重MMP-9的表达有下降趋势;IL-12的表达有升高趋势,有统计学意义。结论与正常妊娠相比妊娠期高血压疾病组胎盘IL-12表达明显增加,MMP-9表达明显下降,且两因子表达与病情正相关。表明两因子参与了妊娠期高血压疾病的发生与发展。

Expression of MMPP-9 and IL-12 in the placenta of pregnancy induced hypertension

Objective: To investigate the pathogenesis of preeclampsia by analyzing the expression of MMP-9and IL-12 in placental of women with preeclampsia and normal pregnance.Methods:Immunohistochemical method was used to detect the expression of IL-12 and MMP-9 of placenta in 28 cases pregnancy induced hypertension and 10cases normal pregnancies.Results: The expression of MMP-9 in the placenta of pregnancy induced hypertension was significantly lower than that in the normal pregnance(P<0.01).Accompanying the aggravation of pathogenetic condition the expression of MMP-9 in pregnancy induced hypertension had a decreased tendency(P<0.01).The expression of IL-12 in the placenta of pregnancy induced hypertension was significantly higher than that of the normal pregnance.And accompanying the aggravation of pathogenetic condition the expression of IL-12 in pregnancy induced hypertension had a increased tendency.Conclusion:The increased IL-12 and decreased MMP-9 are related to the pregnancy induced hypertention with the result of the experiment.