盐酸左氧氟沙星体外抗菌活性的研究

采用试管二倍稀释法测定了盐酸左氧氟沙星对临床分离的279株细菌的最低抑菌浓度（MIC），并与环丙沙星，氧氟沙星作了比较。结果表明：肺炎杆菌，金黄色葡萄球菌，伤寒杆菌及痢疾杆菌对该药甚为敏感，盐酸左氧氟沙星对上述细菌MIC的范围，MIC50，MIC90分别为0．03－128ug/ml,0.03mu/ml,4ug/ml,0.03-128ug/ml,0.06ug/ml,16ug/ml,0.03-64ug/ml,0.03ug/ml,0.125ug/ml;0.03-2ug/ml,0.03ug/ml,2ug/ml，较氧氟沙星抗菌作用强。