子宫内膜癌组织碱性成纤维细胞生长因子表达和微血管密度的临床研究

探讨子宫内膜癌组织碱性成纤维细胞生长因子表达和微血管密度（ＭＶＤ）与临床病理参数和预后的关系。方法采用免疫组织化学技术检测６６例子宫内膜癌组织中ｂＦＧＦ的表达，利用Ⅷ因子相关抗原标记血管内皮细胞，选择能代表肌层浸润深度的切片进行染色。结果子宫内膜癌组织中ｂＦＧＦ有达与病理分级呈明显正相关；子宫内膜癌组织中ＭＶＤ与年龄、病宫内膜癌组织中ｂＦＧＦ表达与病理分级呈明显正相关；子宫内膜癌组织中ＭＶＤ与年龄

Expression of Basic Fibroblastic Growth Factor and Microvessel Density in Endometrial Carcinoma

OBJECTIVE: To investigate the relation of basic fibroblastic growth factor (bFGF) and microvessel density (MVD) with endometrial carcinoma. METHODS: A total of 66 specimens of endometrial carcinoma were evaluated by immunohistochemical technique with polyclonal antibody against bFGF. The microvessels were highlight by immunohistologically staining to detect factor VIII-related antigen. The area of the deepest myometrial invasion was selected for staining. Ninteen specimens of uterine prolapse were used for control. RESULTS: Expression of bFGF was significantly correlated with tumor grade (P < 0.01). MVD was positively correlated with age, tumor grade and myometrial invasion (P < 0.01, respectively). MVD was significantly correlated with expression of bFGF (P < 0.01). Patients with bFGF strong expression and high MVD (> or = 9.4) had worse prognosis (P < 0.01, respectively). CONCLUSIONS: bFGF plays important role in angiogenesis in endometrial carcinoma. Expression of bFGF and MVD could be used as prognostic factors for survival in endometrial carcinoma.