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Characterization of a solitary long terminal repeat of avian endogenous virus origin |
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| Authors: | E J Smith D Bizub D R Scholl A M Skalka |
| Affiliation: | 1. U. S Department of Agriculture, Agricultural Research Service, Regional Poultry Research Laboratory, 3606 East Mount Hope Road, East Lansing, Michigan 48823, USA;2. Department of Cell Biology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110, USA |
| Abstract: | A recombinant lambda phage library constructed with a partial EcoR1 digest of DNA from a normal RPRL line 15B chicken was screened using 32P-labeled plasmid containing Rous-associated virus (pRAV-2). Nucleotide sequence analyses of a fragment of one subclone revealed the presence of a solitary long terminal repeat (LTR) that is similar to the LTRs of avian endogenous retroviruses ev1 and ev2. This LTR is flanked by unique 6 bp direct repeats characteristic of the target site for duplication of avian leukosis viruses. |
| Keywords: | Author to whom correspondence and requests for reprints should be addressed. |
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