| HPLC法测定地苦胆涂膜剂中盐酸巴马汀的含量 |
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| 引用本文： | 陈文生,张明时,夏品华,刘红强,张永萍.HPLC法测定地苦胆涂膜剂中盐酸巴马汀的含量[J].沈阳药科大学学报,2008,25(8):660-662. |
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| 作者姓名： | 陈文生 张明时 夏品华 刘红强 张永萍 |
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| 作者单位： | [1]贵州师范大学分析测试中心,贵州贵阳550001 [2]贵阳中医学院,贵州贵阳550002 |
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| 摘 要： | 目的建立地苦胆涂膜剂中盐酸巴马汀的含量测定方法。方法采用HPLC法,用甲醇做溶剂超声提取,使用十八烷基硅烷键合硅胶为填充剂;甲醇-浓度为0.025 mol.L-1的磷酸缓冲溶液(PH)(体积比为50∶50)为流动相;检测波长为340 nm。结果方法线性关系良好,平均回收率为98.1%,RSD为1.3%。结论HPLC法可以用于测定地苦胆涂膜剂中盐酸巴马汀的含量。
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| 关 键 词： | 地苦胆涂膜剂 盐酸巴马汀 高效液相色谱法 |
| 收稿时间： | 2007-10-15 |
Determination of palmatine hydrochloride in Dikudan film by HPLC |
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| CHEN Wen-sheng,ZHANG Ming-shi,XIA Pin-hua,LIU Hong-qiang,ZHANG Yong-ping.Determination of palmatine hydrochloride in Dikudan film by HPLC[J].Journal of Shenyang Pharmaceutical University,2008,25(8):660-662. |
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| Authors: | CHEN Wen-sheng ZHANG Ming-shi XIA Pin-hua LIU Hong-qiang ZHANG Yong-ping |
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| Institution: | 1.Center of Analysis and Test, Guizhou Normal University, Guiyang 550001, China; 2. Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China |
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| Abstract: | Objective To establish the method of determination of the content of palmatine hydrochloride in Dikukan film. Methods Utrasonic extraction use methanol as solvent, HPLC was used to determine palmatine hydrochloride in Dikudan film on C18. using 0.025 mol·L-1CH3OH-KH2PO4 (V:V=50:50) as mobile phase, with detection at 340 nm. Result The linearity of this method was well. The average recoveries were 98.1% for palmatine hydrochloride. RSD were 1.3 %. Conclusion The method is rapid, accurate, of good reproducibility, and used for quality control of the drug. |
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| Keywords: | Dikudan film palmatine hydrochloride HPLC |
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