Hydrogenated fat diet intake during pregnancy and lactation modifies the PAI-1 gene expression in white adipose tissue of offspring in adult life |
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Authors: | Luciana P Pisani Claudia M Oller do Nascimento Allain A Bueno Carolina Biz Kelse T Albuquerque Eliane B Ribeiro Lila M Oyama |
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Institution: | 1.Department of Physiology, Division of Nutrition Physiology,S?o Paulo Federal University – UNIFESP, Rua Botucatu, Vila Clementino,S?o Paulo,Brazil;2.Department of Bioscience,S?o Paulo Federal University – UNIFESP, v. Ana Costa,S?o Paulo,Brazil |
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Abstract: | We examine whether feeding pregnant and lactating rats hydrogenated fats rich in trans fatty acids modifies the plasma lipid profiles and the expression of adipokines involved with insulin resistance and cardiovascular
disease in their 90-day-old offspring. Pregnant and lactating Wistar rats were fed with either a control diet (C group) or
one enriched with hydrogenated vegetable fat (T group). Upon weaning, the male pups were sorted into four groups: CC, mothers
were receiving C and pups were kept on C; CT, mothers were receiving C and pups were fed with T; TT, mothers were receiving
T and pups were kept on T; TC, mothers were receiving T and pups were fed with C. Pups' food intake and body weight were quantified
weekly and the pups were killed at day 90 of life by decapitation. Blood and carcass as well as retroperitoneal, epididymal,
and subcutaneous white adipose tissues were collected. Food intake and body weight were lower in TC and TT, and metabolic
efficiency was reduced in TT. Offspring of TT and TC rats had increased white adipose tissue PAI-1 gene expression. Insulin
receptor was higher in TT than other groups. Ingestion of hydrogenated vegetable fat by the mother during gestation and lactation
could promote deleterious consequences, even after the withdrawal of the causal factor. |
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