重组人生长激素对慢性腹腔感染病人蛋白质代谢的影响

目的：研究重组人生长激素对促进慢性腹腔感染病人蛋白质代谢的影响。方法：20例慢性腹腔感染病人随机分为GH组（TPN GH）和对照组（TPN），研究时间为10天。分别于研究前与研究结束时进行感染评分，检测血清生长激素（GH）、血清胰岛素样生长因子-1（IGF-1）、血清胰岛素样生长因子结合蛋白-3（IGFBP-3）；分别于研究前、研究第3天、第7天及研究结束时，检测血清白蛋白、前白蛋白转铁蛋白、纤维连接蛋白、C-反应蛋白；测定每天氮平衡及24h尿肌酐。结果：研究结束时GH组GH、IGF-1、IGFBP-3显著高于对照组及研究前；研究期间GH组血清白蛋白、前白蛋白、转铁蛋白、纤维连接蛋白升高，而C-反应蛋白下降；氮平衡改善，累计氮平衡显著高于对照组，而24h尿肌酐则下降。结论：重组人生长激素能促进慢性腹腔感染病人蛋白质代谢，而IGF-1在其中发挥了重要作用。

Influence of recombinant growth hormone on protein metabolism in chronic abdominal infection

Objectives: To study the ameliorated effect of recombinant growth hormone on protein metabolism in chronic abdominal infection. Methods: 20 patients were divided randomly into two groups. Patients in the control group received TPN only for 10 days, while patients in the GH groups received both rGH(13.5u/d) and TPN for 10 days. Sepsis Score grade and detection of serum Growth Hormone (GH), Insulin like growth factor 1 (IGF 1), and Insulin like growth factor binding protein 3(IGFBP 3) were carried out on day 0 and day 11, Serum albumin, prealbumin, transferring, fibronectin and C reaction protein were detected on day 0, day 3, day 7 and day 11, Nitrogen balance and 24 hour urine creatinine secretion were assayed daily. Results: GH, IGF 1 and IGFBP 3 in the GH group on day 11 were significantly higher than those in the GH group on day 0 and those in the control group on day 11, Serum albumin, prealbumin, transferring and fibronectin increased, while C reaction protein decreased when patients were undertaken GH treatment, Nitrogen balance ameliorated and accumulative total nitrogen balance in the GH group was significantly higher than that in the control group, while 24 hour urine creatinine secretion decreased. Conclusions: Recombinant growth hormone can ameliorate protein metabolism in chronic abdominal infection. IGF 1 plays important role in the ameliorated effect of recombinant growth hormone on protein metabolism in chronic abdominal infection.