Immunologic Studies of Factor IX (Christmas Factor) |
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| Authors: | Henry C. Yang |
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| Affiliation: | The New England Area Haemophilia Centre, The Memorial Hospital and Department of Medicine, University of Massachusetts Medical Centre, Worcester, Massachusetts, U.S.A. |
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| Abstract: | A solid-phase two-site immunoradiometric assay has been developed which measures factor IX antigen levels as low as 0.0004 u per ml of plasma. In normal individuals, the factor IX antigen level correlated with the factor IX procoagulant level. In haemophilia B, 14 patients had markedly reduced antigen levels (<0.06 u/ml) and five had normal levels (>0.60 u/ml). |
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