C-Met、MMP-9、TIMP-1在胃癌中的表达及与胃癌侵袭转移的关系

目的　研究肝细胞生长因子受体C Met,基质金属蛋白酶 9(MMP 9)及其组织抑制因子 1(TIMP 1)在胃癌中的表达情况 ,探讨三者的表达与胃癌侵袭转移间的关系及三者间的联系。方法　应用免疫组化方法检测 4 0例胃癌标本中C Met,MMP 9,TIMP 1的表达 ,并进行回顾性随访。结果　伴有淋巴结转移或肝转移的胃癌C Met的阳性表达 ( 5 7.89% ,5 4 .5 5 % )明显高于无转移者 ( 2 7.2 7% ,2 6 .32 %P <0 .0 1)。侵及肌层以上者MMP 9的阳性表达( 6 6 .6 7% )明显高于肿瘤局限于黏膜、黏膜下者 ( 2 0 %P <0 .0 1)。MMP 9阳性表达与胃癌的淋巴转移、肝转移有相关性 (P <0 .0 1)。TIMP 1的表达随胃癌浸润深度增加而减少 ,当肿瘤突破浆膜时TIMP 1的表达呈现陡降趋势 (P <0 .0 1)。MMP 9表达与C Met表达呈明显正相关 (P <0 .0 0 5 )。结论　C Met和MMP 9的过阳性表达可能与胃癌转移行为有关。TIMP 1可能抑制胃癌的浸润转移

C-Met,MMP-9 and TIMP-1 expressions in gastric carcinoma and their relations to invasiveness and metastasis

Objective To study the relationship between expressions of C Met,matrix metalloproteinase 9(MMP 9) and tissue inhibitor of metalloproteinase 1(TIMP 1) and the invasiveness,metastasis in gastric carcinoma.Methods By immunohistochemistry,the expression of C Met,MMP 9 and TIMP 1 in 40 gastric carcinomas were detected,and the patients were followed up.Results The positive expression of C Met and MMP 9 in gastric cancers with lymph node metastases or liver metastases was higher than that without lymph node metastases or liver metastases(P<0.01).The expression of MMP 9 in the tumor invasion beyond musculariis propria was higher than that within lamina propria or submucosa(P<0.01).The relation of the expression of TIMP 1 to the depth of invasion was negative(P<0.01).The relation of C Met was positively related to the expression of MMP 9.Conclusion The expression of C Met and MMP 9 is probably positively related to metastasic behavior of gastric carcinoma.The expression of TIMP 1 probably inhibit tumor metastasis.