子宫腺肌症病变中雌激素、孕激素、癌基因、凋亡抑制基因的表达研究

目的 研究雌激素（ER）、孕激素（PR）及癌基因（cerbB-2）、凋亡抑制基因（Bcl-2）在子宫腺肌症病变中的表达和子宫腺肌症发病的相关性。方法 用免疫组化方法检测40例子宫腺肌症病变组织中ER及其他生物学指标的表达。结果 ER、PR与CerbB．2、Bcl-2在子宫腺肌症病变中均有不同程度的阳性表达，子宫肌层异位内膜ER阳性表达率97．5％，PR阳性率97．5％，cerbB-2阳性率82．5％，Bcl-2阳性率62．5％。在位内膜和异位内膜ER、PR均呈阳性，阳性率比较差异无统计学意义（P〉0．05）。异位内膜cerbB-2的强阳性率高于在位内膜，差异有统计学意义（P〈0．05）。ER、PR与cerbB-2、Bcl-2阳性率相比具有相关性（P〈0．05）。结论 ER、PR与cerbB．2、Bcl-2在异位内膜高表达，提示这些生物学指标在子宫腺肌症发生发展中发挥作用。

Expression correlation of ER to PR, cerbB-2 genes, and Bcl-2 in adenomyosis uterus

Objective To investigate the expression of ER,PR,cerbB-2 and Bcl-2 in adenomyosis and their correlation with pathogenesis. Methods The expressions of ER, PR, cerbB-2,and Bcl-2 in 40 cases of adenomyosis were assayed by En Vision immunohistochemical methods. Results The positive rates of ER,PR, cerbB-2 and Bcl-2 protein in ectopic endometrium of myometrium were 97.5%,97.5%, 82.5% and 62. 5 % , respectively. Both the eutopic and ectopic endometrium in 40 cases showed ER,PR positive. The positive expression rate had no significant differences(P>0.05). The strong positive rate of cerbB-2 in the cetopic endometrium was significantly higher than that eutopic in the(P<0.05).The expression of ER,and PR had a positive correlation with the expression of cerbB-2,and Bcl-2(P<0.05). Conclusion ER,PR,cerbB-2 and Bcl-2 are overexpresscd in the eutopic and ectopic endometrium. They play important roles in the progression of adenomyosis.