| 杜仲红景天胶囊对大鼠脑缺血的保护作用 |
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| 引用本文： | 陈云华,张硕峰,孙建宁,吴金英,贾占红.杜仲红景天胶囊对大鼠脑缺血的保护作用[J].中国中医药信息杂志,2006,13(12):30-32. |
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| 作者姓名： | 陈云华 张硕峰 孙建宁 吴金英 贾占红 |
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| 作者单位： | 1. 北京城市学院生物技术学部,北京,100094;北京中医药大学中药学院,北京,100102
2. 北京中医药大学中药学院,北京,100102 |
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| 摘 要： | 目的研究杜仲红景天胶囊对脑缺血的保护作用,为其治疗脑缺血提供药理学依据。方法采用三氯化铁致大脑中动脉血栓形成(MCAO)大鼠模型,观察杜仲红景天胶囊对缺血性中风的保护作用;采用双侧颈总动脉结扎大鼠模型观察杜仲红景天胶囊对脑毛细血管通透性的影响。结果杜仲红景天胶囊能改善MCAO大鼠神经症状、降低脑梗死比、减轻脑水肿,还能增加缺血区脑组织血流量,降低双侧颈总动脉结扎大鼠脑毛细血管通透性。结论杜仲红景天胶囊对脑缺血有较好的保护作用。
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| 关 键 词： | 杜仲红景天胶囊 脑缺血 大脑中动脉血栓 毛细血管通透性 大鼠 |
| 文章编号： | 1005-5304（2006）12-0030-03 |
| 收稿时间： | 2006-04-24 |
| 修稿时间： | 2006年4月24日 |
Effect of Duzhonghongjingtian Capsule on Experimental Cerebral Ischemia in Rats |
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| CHEN Yun-hua,ZHANG Shuo-feng, SUN Jian-ning, et al.Effect of Duzhonghongjingtian Capsule on Experimental Cerebral Ischemia in Rats[J].Chinese Journal of Information on Traditional Chinese Medicine,2006,13(12):30-32. |
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| Authors: | CHEN Yun-hua ZHANG Shuo-feng SUN Jian-ning |
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| Institution: | 1.Beijing City University, Beijing 100094, China; 2.Beijing University of TCM, Beijing 100102, China |
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| Abstract: | Objective To study the protective effect of Duzhong Hongjingtian Capsule (DHC) on cerebral ischemia in rats. Methods Thrombotic ischemia and middle cerebral artery occlusion (MCAO) induced by FeCl3 in rats was used to observe the protective effect of DHC on ischemia stroke, and common carotid artery occlusion (CCAO) rats was used to analyze the effect of DHC on blood brain barrier (BBB) permeability. Results DHC could improve the abnormal behavior of MCAO rats and decrease the infarction area and water content in the brain of MCAO rats. DHC could also improve the cerebral blood flow on MCAO rats and significantly reduce the permeability for evans' blue (EB) of CCAO rats. Conclusions DHC can protect the brain ischemic injury. |
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| Keywords: | Duzhong Hongjingtian capsule cerebral ischemia middle cerebral artery occlusion capillary vessel permeability rat |
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