| ANTITUMOR EFFECTS OF POLYETHYLENE GLYCOLMODIFIED RECOMBINANT HUMAN INTERLEUKIN-2 ON MOUSE UTERINE CERVICAL CARCINOMA IN VIVO |
| |
| 引用本文： | 王立夫,吴裕炘,章永平,唐微,刘新垣. ANTITUMOR EFFECTS OF POLYETHYLENE GLYCOLMODIFIED RECOMBINANT HUMAN INTERLEUKIN-2 ON MOUSE UTERINE CERVICAL CARCINOMA IN VIVO[J]. 中国癌症研究, 1997, 0(1) |
| |
| 作者姓名： | 王立夫 吴裕炘 章永平 唐微 刘新垣 |
| |
| 作者单位： | Wang Lifu ; Wu Yuxin; ZhangYongping;Tang Wei; Liu Xinyuan (Department of Internal Medicine，Rui Jin Hospital，Shanghai Second Medical University Shanghai 200025)(Institute of Biochemistry Academia Sinima 200031) |
| |
| 摘 要： | Rqcombinanthumaninterleukin-2(rIL-2)isoneofthecytokines,whichplananimportantroleinantitllmorimmunotherapy.However,rIL-2haslimitedsolubility,andrIL-2israpidlyclearedfromcirculationofhumanwhenitisinjectedintohuman,resultinginshort-termplasmahalf-lifeandlimitedclinicalapplication.WehavemodifiedrIL-2bypolyethyleneglycol(PEG),whichincreaseditssolubilityandprolongeditsplasmahalf-life.Inthispaper,theantitumoreffectsofPEG-modifiedrecombinanthumaninterleukin-2(PEG-rIL-2)againstmouseuterinecervi…
|
ANTITUMOR EFFECTS OF POLYETHYLENE GLYCOLMODIFIED RECOMBINANT HUMAN INTERLEUKIN-2 ON MOUSE UTERINE CERVICAL CARCINOMA IN VIVO |
| |
| Wang Lifu , Wu Yuxin, ZhangYongping,Tang Wei, Liu Xinyuan. ANTITUMOR EFFECTS OF POLYETHYLENE GLYCOLMODIFIED RECOMBINANT HUMAN INTERLEUKIN-2 ON MOUSE UTERINE CERVICAL CARCINOMA IN VIVO[J]. Chinese Journal of Cancer Research, 1997, 0(1) |
| |
| Authors: | Wang Lifu Wu Yuxin ZhangYongping Tang Wei Liu Xinyuan |
| |
| Abstract: | Polyethylene glycol (PEG-8000)-modified recombinant human interleukin-2 (PEG-rIL-2) is a cytokine with prolonged circulatory half-life. In this paper, the antitumor effects of PEG-afL-2 against mouse uterine cervical carcinoma (U14) transplanted intraperitoneally or subcutaneously is reported. PEG-rIL-2 at different doses was administered intraperitoneally. The results showed that PEG-rIL-2 (4500 IU, i.p., QD5) prolonged survival time of mice bearing ascites tumor as compared to rIL-2 (P<0.01), but PEG-rIL-2 at lower doses was without therapeutic effect. In addition, compared to rIL-2, PEG-rIL-2 at different doses (1500-13500 IU, s.c.,QD5) caused significant dose-dependent growth inhibition of solid tumor (P<0.01) when the treatment started at day 4 after subcutaneous inoculation of tumor. |
| |
| Keywords: | Cervix neoplasms/therapy Polyethylene glycol Interleukin-2 Immunotherapy |
| 本文献已被 CNKI 等数据库收录！ |
|
