N-乙酰半胱氨酸治疗慢性阻塞性肺疾病急性加重期的疗效分析

目的观察应用N-乙酰半胱氨酸(NAC)治疗慢性阻塞性肺疾病(COPD)急性加重期的疗效。方法将68例COPD急性加重期患者随机分为治疗组和对照组,各34例,两组患者酌情使用茶碱缓释剂及抗生素治疗,治疗组在此基础上给予口服NAC治疗,200mg/次,3次/d,均于餐后服用,疗程14d。观察治疗前后两组患者咳嗽、咳痰、气促等临床症状及肺功能包括治疗前后第一秒钟用力呼气容积(FEV1)、第一秒钟用力呼气容积占用力肺活量的比值(FEV1/FEC%)和FEV1占预计值百分比变化情况。结果两组疗效比较差异有统计学意义(P<0.05)。治疗组治疗后肺功能各项指标与对照组比较差异均有统计学意义(P<0.05)。治疗组无明显不良反应。结论NAC用于COPD急性加重期患者可以减轻气流阻塞,防止氧化应激,改善患者的呼吸功能,且使用安全。

Effect of N-acetylcysteine in Treatment of AECOPD

Objective To investigate the effect of N-acetylcysteine (NAC) in treatment of acute episode of chronic obstructive pulmonary disease (AECOPD).Methods Totally 68 patients with AECOPD were divided into two groups randomly,with 34 in each group.All patients were treated with Slow-release theophyline or antibiotic while patient need.The patients in the trial group were additionally given 200 mg NAC granulated powder orally after meal,three times daily.The course of treatment was 14 days.The changes of symptoms such as cough,expectoration and dyspnia,as well as pulmonary functions including FEV1,FEV1/FEC% and predictive percentage of FEV1 of the patients in the two groups before and after the treatment were observed.Results There was significant difference in effect between the two groups (P<0.05).After treatment the pulmonary function of the patients in the trial group was obviously improved as compared with the control group (P<0.05).And no untoward reaction was found in the trial group.Conclusion NAC can alleviate airway obstruction,avoid oxidative stress,improve pulmonary function in treatment of AECOPD patients,and it is safe.