国产长春瑞滨联合顺铂治疗转移性乳腺癌的临床观察

目的：观察国产长春瑞滨(盖诺)联合顺铂方案治疗转移性乳腺癌的临床疗效。方法：运用盖诺(25mg／m^2 IV dl，d8)加顺铂(DDP80mg／m^32 IV d1)治疗转移性乳腺癌26例。结果：取得CR3例(11．5％)，PR12例(46．1％)，总有效率RR(CR PR)达57．6％。主要毒副作用为骨髓抑制，胃肠道反应和静脉炎。白细胞减少的发生率100％，其中Ⅲ-Ⅳ度达57．7％。恶心、呕吐的发生率92．3％，Ⅲ-Ⅳ度达11．5％。静脉炎的发生率15．4％。结论：国产长春瑞滨联合顺铂对转移性乳腺癌疗效确切，且毒性可以耐受，可以作为对蒽环类药物治疗后复发，转移乳腺癌患者的二线治疗方案。

Combination Chemotherapy With Vinorelbine and Cisplatin in the Treatment of Metastatic Breast Cancer

Objective:To evaluate the effective of combination chemotheraphy of NVB plus cisplatin on metastatic breast cancer.Methods:26 patients of metastatic breast cancer were treated with NVB 25mg/m 2 IVD for day1 and day8 and cisplatin 80mg/m 2 IV for day1.Results:Complete response was observed in 3 patients,partial response in 12 patients,with an overall response rate of 57.6%,The most common toxicities were seen myelosuppression,vomiting and phlebitis.Leukopenia was observed in all patients(100%) and grade 3 and grade 4 leukopenia in most of patients(57.7%).The rates of vomiting were 92.3%,and grade 3 and grade 4 vomiting were 11.5%.The rates of phlebitis were 15.4%.Conclusion:The NP combination chemotheraphy was effective for metastatic breast cancer and the toxicities were tolerable,It serves as the second line chemotherapy regimen on patient with anthracycline-resistant metastatic breast cancer.