新生儿神经行为测定对纳络酮治疗缺氧缺血性脑病的评价

目的 探讨纳络酮治疗缺氧缺血性脑病的有效性及临床价值。方法 随机分成观察组(n=40)与对照组(n=45)。用纳络酮治疗HIE患儿，并与同期未用纳络酮治疗的患儿进行临床对照研究。两组在治疗前后进行20项NBNA测试。结果 本组与对照组差异显著。结论 新生儿缺氧缺血性脑病加用纳络酮治疗，疗效确切，值得推广。

The Evalultion of Neonatal Behaviotal Neurological Assessment on the treatment of hypoxic- ischemic encephalopathy with Naloxone

Objective To study the efficacy and clinical value of naloxone in the therapy for neonatal hypoxic-ischemic encephalopathy(HlE).Methods Neonates with HIE were divided into two groups of routine (45) and naloxone treatments (4). The study was a controlled clinical trial. neonates with HIE were treated with naloxone and an other newborn infants with HIE who received no naloxone were enrolled as control group between April 2001 and August 2003.Before and after treatment,the expression of the two groups was detected by Neonatal Behavioral Neurological Assessment (NBNA).Results There were significant differences in the improvement of Neonatal Behavioral Neurological Assessment between the two groups (P<0.01).Conclusions Naloxone was efective in the treatment of neonatal HIE.