长春瑞滨联合同步三维适形放疗治疗局部晚期非小细胞肺癌的临床研究

目的 评价长春瑞滨联合同步三维适形放疗在局部晚期非小细胞肺癌治疗中的近期疗效和毒副反应.方法 84例符合NSCLC诊断标准的患者随机分为两组,治疗组42例,对照组42例.两组在常规治疗的基础上,治疗组给予长春瑞滨和顺铂静脉滴注,并同步三维适形放疗,对照组给序贯化放疗治疗.结果 治疗组有效率(CR+PR)86.1%,1年生存率73.8%.对照组有效率(CR+PR)51.9%,1年生存率35.7%,两组差异有统计学意义.结论长春瑞滨与三维适形放疗同步方案能提高局部晚期非小细胞肺癌的近期疗效,且毒副反应无明显增加,值得进一步随访研究.

Clinical study of Navelbine and concurrent three-dimensional conformal radiotherapy(3D-CRT) in the treatment of locally advanced non-small cell lung cancer

Objective To evaluate the clinical effect of navelbine and concurrent three-dimensional eonformal radiation therapy (3 D-CRT)for locally advanced non-small cell lung cancer(NSCLC). Methods Ac-cording to the different grades and eharaeteristie of organism of NSCLC,we treated 42 NSCLC patients by 3D-CRT combined with chemotherapy of navelbine and eisplatin. Other 42 patients were treated by chemotherapy and sequential 3D-CRT(as control group). Results In therapy group, the overall response rate(CR+PR)was 86.1% and one-year survival rate was 73.8%. In control group, the overall response rate (CR+PR) and one-year survival rate wero 51.9% and 35.7 % respectively. The difference shows signilieant (P<0.05). Conclusion Concurrent application of novelbine and 3D-CRT can improve the overall response rate for locally advanced NSCLC without aggravating toxicity.