小剂量胺碘酮预防老年人阵发性心房纤颤复发的疗效和安全性

目的 :探讨口服小剂量胺碘酮 (AD)预防老年人非瓣膜性心脏病阵发性房颤复发的疗效。方法 :40例老年阵发性房颤患者 ,给予AD6 0 0mg·d- 1 ,6d后渐减为维持量 5 0～ 1 0 0mg·d- 1 ,2 4h动态心电图观察评价其疗效。结果 :服药后 6月 ,1 2月和 2 4月 ,AD维持窦性心律的有效率分别为 90 0 % ,83 3 %和 72 7% ,因副作用停药者仅 5 % (2 /40 )。结论 :小剂量AD(5 0～ 1 0 0mg·d- 1 )可有效、安全的预防老年人阵发性房颤的复发。

Efficacy and safety of low dose amiodarone for paroxysmal atria l fibrillation in the aged patients with no-valvular heart diseases

Objective To study the efficacy and safety of low-dose amiodarone (AD) for paroxysmal atrial fibrillation in the aged patients with no-valvular heart diseases. Method 40 inpatients were treated with load-dose AD (600?mg·d -1 ) for 6 days and then low maintenance dose of 50?mg or 100?mg daily. Clinical efficacy was evaluated with 24?h dynamic electrocardiogram. Results AD maintained efficaciously sinus rhythm about 90.0%(36/40) during 6 months, about 83.3% (25/30) during 12 months, about 72.7% (16/22) during 24 months. Only 2 patients were stopped oral AD because sinus bradycardia(≤45?bpm) occurred. Conclusion Low dose AD (50～100?mg·d -1 ) is a safe and efficinet maintenance of sinus rhythm in aged patients with no-valvular heart diseases and paroxysmal atrial fibrillation.