Sex steroid replacement in post-menopausal women: effects on thyroid hormone status |
| |
| Authors: | H I Abdalla G Beastall D Fletcher J S Hawthorn J Smith D M Hart |
| |
| Affiliation: | 1. Departments of Obstetrics and Gynaecology, Stobhill General Hospital, Glasgow, U.K.;2. Department of Biochemistry, Stobhill General Hospital, Glasgow, U.K.;3. Department of Biochemistry, Royal Infirmary, Glasgow, U.K.;1. Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy;2. Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway;1. UMR 1198 Developmental Biology and Reproduction, French Institute for Agricultural Research (INRA), Jouy-en-Josas, France;2. Experimental farm, French Horse and Riding Institute (IFCE), Chamberet, France;1. Department Large Animal Clinical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;2. Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;3. Department of Veterinary Pathology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;1. Department of Large Animal Clinical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;2. Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada |
| |
| Abstract: | We have measured serum thyroxine (T4), triidothyronine (T3), thyroid-stimulating hormone (TSH) free thyroxine (FT4) and thyroxine-binding globulin (TBG) levels in a total of 5 post-menopausal women who were receiving oestrogen alone (Premarin, n = 19), progestogen alone (Primolut-N, n = 12), a combination of oestrogen and progestogen (Prempak C, n = 14) or no treatment (control group, n = 12). No differences were observed between the Premarin and Prempak C groups; both exhibited elevated T4 and TBG levels, although free thyroxin (FT4) and T4/TBG concentrations were normal relative to those in the control group. The Primolut-N subjects showed subnormal T3 and FT4 levels relative to the controls. It was concluded that it is not possible to make general statements regarding the effects of sex steroids on FT4 levels. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
