成纤维细胞生长因子21的研究进展

随着2型糖尿病发病率的增加,寻找一种更加安全有效的治疗药物已成为全球关注的问题,成纤维细胞生长因子21(FGF21)的代谢调节功能与胰岛素类似,并在很多方面优于胰岛素,因此FGF21有望成为代替胰岛素治疗糖尿病的新药。FGF21在2型糖尿病的动物模型中有较强的作用,主要作用于脂肪组织和胰腺,可以改善与肥胖有关的高血糖和高血脂,并在饥饿和酮症时发挥关键的调控作用。

Research Progress and Clinical Observation of Fibroblast Growth Factor 21

As the incidence rate of type 2 diabetes increases,a more safe and effective treatment has been an issue of global concern.The metabolic function of fibroblast growth factor 21(FGF21) is similar to that of insulin,but better than insulin in many ways.Therefore,FGF21 is probably a new antidiabetic drug in replace of insulin therapy.FGF21 has a strong effect on the animal models of type 2 diabetes,mainly acting on adipose tissue and pancreas.It can improve the obesity-related hyperglycemia and hyperlipidemia and play a key role in the regulation of starvation and ketosis.This paper reviews the research progress and clinical observation of FGF21.