| 川木香煨制前后药效成分在大鼠胃、小肠、结肠中吸收差异研究 |
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| 引用本文： | 高 飞,傅超美,胡慧玲,王战国,彭 伟,卢君蓉,盛菲亚,毛 茜.川木香煨制前后药效成分在大鼠胃、小肠、结肠中吸收差异研究[J].中草药,2013,44(20):2872-2877. |
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| 作者姓名： | 高 飞 傅超美 胡慧玲 王战国 彭 伟 卢君蓉 盛菲亚 毛 茜 |
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| 作者单位： | 1.成都中医药大学药学院 中药材标准化教育部重点实验室 中药资源系统研究与开发利用省部共建国家重点实验室培育基地，四川 成都 611137 2.四川大学生命科学院，四川 成都 610041 |
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| 基金项目： | 国家自然科学基金青年基金资助项目（81001638） |
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| 摘 要： | 目的 比较川木香煨制前后主要药效成分木香烃内酯和去氢木香内酯在大鼠胃、小肠、结肠的吸收差异。方法 建立大鼠原位胃、小肠、结肠吸收灌注模型，HPLC-UV法测定给药后各灌注液中木香烃内酯、去氢木香内酯和酚红的量，获取川木香煨制前后主要药效成分在胃、小肠、结肠中吸收动力学参数。结果 川木香生品中木香烃内酯和去氢木香内酯在大鼠胃和小肠中的每小时吸收百分率较煨制品高（P＜0.05），川木香煨制品中木香烃内酯和去氢木香内酯在结肠中的每小时吸收百分率较生品高（P＜0.01）。结论 川木香煨制品中药效成分在结肠中吸收速度高于生品。
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| 关 键 词： | 川木香 煨制 胃肠吸收 木香烃内酯 去氢木香内酯 |
Comparative study on absorption of effective components from roasting-processed and crude Vladimiriae Radix in stomach, small intestine, and colon of rats |
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| GAO Fei,FU Chao-mei,HU Hui-ling,WANG Zhan-guo,PENG Wei,LU Jun-rong,SHENG Fei-y,MAO Qian.Comparative study on absorption of effective components from roasting-processed and crude Vladimiriae Radix in stomach, small intestine, and colon of rats[J].Chinese Traditional and Herbal Drugs,2013,44(20):2872-2877. |
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| Authors: | GAO Fei FU Chao-mei HU Hui-ling WANG Zhan-guo PENG Wei LU Jun-rong SHENG Fei-y MAO Qian |
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| Institution: | 1.Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development, and Utilization of Chinese Medicine Resources, Ministry of Education, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China 2.College of Life Science, Sichuan University, Chengdu 610041, China |
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| Abstract: | Objective To analyze the absorption difference of the principal active components in Vladimiriae Radix, costunolide and dehydrocostuslactone, between the crude Vladimiriae Radix (CVR) and roasting-processed Vladimiriae Radix (RPVR), in stomach, small intestine, and colon in rats. Methods The in situ perfusion models of stomach, small intestine, and colon in rats were established, the contents of costunolide, dehydrocostuslactone, and phenol red were determined using HPLC-UV method, and the parameters of absorption kinetics of the test object in stomach, small intestine, and colon were obtained. Results The absorption percentage per hour of costunolide and dehydrocostuslactone in CVR was higher than that in RPVR in stomach and small intestine of rats (P < 0.05). However, the absorption percentage per hour of costunolide and dehydrocos in RPVR was higher than that in CVR in colon of rats (P < 0.01). Conclusion The absorption rate of cstunolide and dehydrocostuslactone in CVR is higher than that in PVR sample in colon of rats. |
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| Keywords: | Vladimiriae Radix roasting in ashes in situ stomach intestinal absorption costunolide dehydrocostuslactone |
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