醒脑静不同制剂给大鼠鼻单向灌流后龙脑和麝香酮吸收比较研究

目的 比较醒脑静不同制剂给大鼠鼻单向灌流后其有效成分龙脑和麝香酮吸收特征。方法 采用大鼠在体鼻单向灌流模型，GC法测定灌流液中龙脑和麝香酮的量，比较醒脑静滴鼻液与醒脑静微乳中龙脑和麝香酮在大鼠鼻腔的吸收。结果醒脑静滴鼻液中龙脑吸收速率常数（K_a）为（1.00±0.02）min^?1，醒脑静微乳中龙脑K_a为（0.76±0.03）min^?1；醒脑静滴鼻液中麝香酮K_a为（0.76±0.02）min^?1，醒脑静微乳中麝香酮K_a为（0.58±0.10）min^?1。结论 醒脑静滴鼻液中龙脑和麝香酮在鼻腔的吸收均较醒脑静微乳快。

Comparative study on absorption of Luodian Borneolum and muscone after nasal unidirectional perfusion with different Xingnaojing preparations in rats

Objective To compare the absorption characteristics of Luodian Borneolum and muscone after nasal unidirectional perfusion with different Xingnaojing preparations in rats. Methods The nasal unidirectional perfusion model was used, the contents of Luodian Borneolum and muscone were determined by GC method, and the absorption of Luodian Borneolum and muscone in Xingnaojing Nasal Drop (XN) and Xingnaojing Microemulsion (XM) were compared. Results The absorption rate constants (K_a) of Luodian Borneolum in XN and XM were (1.00 ± 0.02) and (0.76 ± 0.03) min^?1, respectively, and the K_a values of muscone in XN and XM were (0.76 ± 0.02) and (0.58 ± 0.10) min^?1, respectively. Conclusion The absorption of Luodian Borneolum and muscone in XN are both faster than that in XM.