Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors |
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| Authors: | Robert Séverine Bertolla Carine Masereel Bernard Dogné Jean-Michel Pochet Lionel |
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| Affiliation: | Department of Pharmacy, Drug Design and Discovery Center, FUNDP, University of Namur, Namur, Belgium. |
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| Abstract: | Recently, FXIIa was highlighted as an original attractive target for the development of new anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe the development of a new series of 3-carboxamide-coumarins that are the first potent and selective nonpeptidic inhibitors of FXIIa. |
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