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Oxidative stress and recurrent aphthous stomatitis |
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| Authors: | Jose Bagan Guillermo Saez Carmen Tormos Carmen Gavalda Jose M Sanchis Leticia Bagan Crispian Scully |
| Institution: | 1. Oral Medicine Department, Service of Stomatology and Maxillofacial Surgery, University General Hospital, University of Valencia, Avda/Tres Cruces s/n, 46014, Valencia, Spain 2. Department of Biochemistry, School of Medicine, University of Valencia, Valencia, Spain 3. University College London, London, UK |
| Abstract: | ObjectivesThis study analyzed the oxidative stress status in patients with recurrent aphthous stomatitis (RAS) in the presence and absence of active ulceration.Material and methodsOxidative stress was analyzed in peripheral mononuclear cells of 28 RAS patients with active ulceration and 29 controls. A further blood sample was collected from nine subjects randomly selected from the 28 RAS cases, during the period in which the patients did not have active oral ulceration. The reduced glutathione (GSH), malondialdehyde (MDA), and oxidized glutathione (GSSG) levels were measured in these samples.ResultsThe mean MDA and GSSG levels were significantly higher in patients with active RAS than in the controls, while GSH was lower in the RAS group (p?p?Conclusions Oxidative stress was detected in our RAS patients. |
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