铁调节蛋白2基因多态性与阿尔茨海默病及血管性痴呆的相关分析 |
| |
引用本文: | 林康广,唐牟尼,郭扬波,韩海英,林育华,马崔,王阳顺. 铁调节蛋白2基因多态性与阿尔茨海默病及血管性痴呆的相关分析[J]. 中华精神科杂志, 2003, 42(1): 97-101. DOI: 10.3760/cma.j.issn.1006-7884.2009.02.013 |
| |
作者姓名: | 林康广 唐牟尼 郭扬波 韩海英 林育华 马崔 王阳顺 |
| |
作者单位: | 广州医学院附属广州市精神病医院老年精神科,510370;广州医学院附属广州市精神病医院中心实验室,510370; |
| |
基金项目: | 广州市医药卫生科技基金 |
| |
摘 要: | Objective To evaluate the association of 2616c/T polymorphism in iron regulatory protein 2(IRP2)gene with Alzheimer disease(AD)and Vascular dementia(VD).Methods In this study,281 patients with AD,60 with VD,and 285 normal aged were recruited.The 2616C/T polymorphism in IRP2 gene was analyzed by using polymerase chain reaction-restriction fragment length polymorphism.And the cognitive function was assessed with the Mini-Mental State Examination(MMSE).Results (1)No significant difieFences were demonstrated in IRP2 genotype or allele frequencies between AD patients and controls(χ2=2.46,P=0.292;χ2=2.17,P=0.141 respectively).However,when AD patients were stratified by disease severity.the frequency of T allele carriers in the moderate to severe AD patients was 78.0%,significantly higher than that in controls(69.8%;χ2=4.106,P<0.05).Logistic regression analysis demonstrated that the age-,sex-and ApoE-adiusted OR of modcrate to severe AD patient with T allele was 1.62(95% CI=1.03-2.54).The frequency of T allele carriers or T allele in VD patients was higher than that of controls,but the difference was not statistically significant(P>0.05).(2)The frequency of tit genotype or T allele in the moderate to severe AD patients was significantly higher than that in mild AD patients(25.8%vs.12.5%,χ2=5.477,P<0.05;51.9%vs.40.3%,χ2=5.803,P<0.05 respectively).(3)MMSE scores of the AD patients with TT genotype was significantly lower than ones with CC or CT genotype(P=0.028;P=0.014 respectively).Conclusion The 2616C/T polymorphism in the IRP2 gene is possibly associated with moderate to severe AD.but not associated with VD.And the TT genotype may be a risk factor for cognitive impairment of patients with AD in Chinese Han.
|
关 键 词: | 阿尔茨海默病 痴呆,血管性 铁调节蛋白质2 多态性,单核苷酸 认知 |
The correlation between 2616C/T polymorphism in iron regulatory protein 2 gene and Alzheimer disease, vascular dementia |
| |
Abstract: | |
| |
Keywords: | Alzheimer diseaseDementia vascularIron regulatory protein 2Polymorphism single nucleotideCognition |
|
|