| Abstract: | The authors researched into the mechanisms through which the sympathetic nerve intensifies the vagal stimulation of the gastroduodenal, urinary bladder, uterine and deferent duct motility and the vagal inhibition of heart functioning. It was shown that these phenomena are mediated by preganglionic serotoninergic fibers conducting excitement to intramural serotoninergic neurons. The study found a growing cranio-caudal gradient of the serotoninergic innervation of visceral organs. The mechanism of gastroduodenal motility activation includes intramural serotoninergic neurons, which conduct excitement to 5-HT1,2 -serotonin receptors of the effector tissues. A model of myocarditis and experimental gastric ulcer demonstrated the cardio- and gastroduodenoprotectory effects of the serotonin blockers. |
