| 骨髓间充质干细胞治疗兔膝RA模型软骨损伤的MRI评价 |
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| 引用本文： | 周钟珩,崔延安,刘钊,刘红霞,黄海青,张全彬.骨髓间充质干细胞治疗兔膝RA模型软骨损伤的MRI评价[J].中国临床医学影像杂志,2011,22(7):479-482. |
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| 作者姓名： | 周钟珩 崔延安 刘钊 刘红霞 黄海青 张全彬 |
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| 作者单位： | 1. 江苏省中医院MR室,江苏南京,210029
2. 南京医科大学附属南京第一医院骨科中心,江苏南京,210006 |
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| 基金项目： | 江苏省自然科学基金面上项目 |
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| 摘 要： | 目的：用骨髓间充质干细胞治疗兔早期类风湿关节炎，运用MRI测量软骨厚度，观察前后改变，评价治疗效果。方法：选取42只新西兰大白兔，用卵蛋白造模，造模第4周（治疗前）取6只兔行MR和病理检查以对照，余36只兔随机分为RA模型组和BMSCs治疗组，每组18只，两组于治疗后1、2、3个月分别选取6只兔行MR和病理检查。对病变膝关节的软骨厚度进行MRI测量及病理学评分，并对数据进行统计学分析。结果：RA组经1、2、3个月后，软骨厚度变薄，病理学评分增加。BMSCs治疗组治疗1、2、3个月后，关节软骨厚度恢复，病理学评分减低。MRI测量数据和病理学评分有相关性。结论：MRI可用于评价BMSCs治疗早期类风湿关节炎关节软骨的改变。
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| 关 键 词： | 间质干细胞 关节炎 类风湿 兔 磁共振成像 |
| 收稿时间： | 2010-11-17 |
MRI evaluation of bone marrow mesenchymal stem cells in the treatment of cartilage damage in RA rabbit model |
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| ZHOU Zhong-heng,CUI Yan-an,LIU Zhao,LIU Hong-xia,HUANG Hai-qing,ZHANG Quan-bin.MRI evaluation of bone marrow mesenchymal stem cells in the treatment of cartilage damage in RA rabbit model[J].Journal of China Clinic Medical Imaging,2011,22(7):479-482. |
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| Authors: | ZHOU Zhong-heng CUI Yan-an LIU Zhao LIU Hong-xia HUANG Hai-qing ZHANG Quan-bin |
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| Institution: | ZHOU Zhong-heng1,CUI Yan-an1,LIU Zhao1,LIU Hong-xia1,HUANG Hai-qing1,ZHANG Quan-bin2(1.Department of MR,Jiangsu Province Hospital of TCM,Nanjing 210029,China,2.Department of Orthopedics,Nanjing First Hospital Affiliated of Nanjing Medical University,Nanjing 210006,China) |
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| Abstract: | Objective:To observe the effects of bone marrow stem cells(BMSCs) transplantation in treating rheumatoid arthritis(RA) in rabbits by measuring the thickness of knee joint articular cartilage using MRI.Methods:Ovalbumin was used to induce right knee rheumatoid arthritis in 42 New Zealand white rabbits.Four wks later,MRI and pathologic examination were carried out in 6 rabbits,the remaining 36 rabbits were randomly and equally divided into the RA group as control and the BMSCs transplantation group.Normal sal... |
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| Keywords: | Mesenchymal stem cells Arthritis rheumatoid Rabbits Magnetic resonance imaging |
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