| 千金藤素对大鼠体内非索非那定药动学的影响 |
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| 引用本文： | 胡玉琴,蒋学华,于志瀛,陶勇,黄美兰.千金藤素对大鼠体内非索非那定药动学的影响[J].医药导报,2011,30(8):991-993. |
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| 作者姓名： | 胡玉琴 蒋学华 于志瀛 陶勇 黄美兰 |
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| 作者单位： | 1. 广东食品药品职业学院,广州,510520
2. 四川大学华西药学院临床药学与药事管理学系,成都,610041 |
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| 摘 要： | 目的研究千金藤素对大鼠体内非索非那定药动学的影响。方法SD大鼠10只随机分为两组，分别灌胃给予非索非那定、千金藤素+非索非那定，不同给药时间采集血样。采用高效液相色谱法测定非索非那定血药浓度，绘制药物浓度 时间曲线，用3P97药动学软件拟合药动学参数，并进行统计分析。结果非索非那定和千金藤素+非索非那定组Cmax分别为（1.225±0.770），（1.417±0.440） μg•mL 1 （P＜0.05）；AUC0 t分别为（5.379±1.570），（8.088±1.760） mg•h•L 1（P＜0.01）。千金藤素＋非索非那定组AUC0 t和Cmax分别增加7.09%（P＜0.05）和15.67%（P＜0.05）；两组Ka、 MRT和t1/2差异无统计学意义。结论与千金藤素合用后，非索非那定在大鼠体内的生物利用度增加，千金藤素对非索非那定在大鼠体内药动学具有显著影响。
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| 关 键 词： | 千金藤素 非索非那定 色谱法 高效液相 药动学 |
Effect of Cepharanthine on Pharmacokinetics of Fexofenadine in Rats |
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| HU Yu-qin,JIANG Xue-hua,YU Zhi-ying,TAO Yong,HUANG Mei-lan.Effect of Cepharanthine on Pharmacokinetics of Fexofenadine in Rats[J].Herald of Medicine,2011,30(8):991-993. |
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| Authors: | HU Yu-qin JIANG Xue-hua YU Zhi-ying TAO Yong HUANG Mei-lan |
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| Institution: | HU Yu-qin1,JIANG Xue-hua2,YU Zhi-ying1,TAO Yong1,HUANG Mei-lan1(1.Guangdong Food and Drug Vocation College,Guangzhou 510520,China,2.Department of Clinical Pharmacy and Pharmacy Administration,West China School of Pharmacy,Sichuan University,Chengdu 610041,China) |
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| Abstract: | Objective To study the effect of cepharanthine on pharmacokinetics of fexofenadine in rats.Methods 10 rats were randomly divided into two groups,which were treated with fexofenadine as group A and fexofenadine plus cepharanthine as group B.The blood samples were collected at different time points from two groups.The serum concentration of fexofenadine sodium was determined by HPLC and the pharmacokinetic parameters were calculated with 3P97 program and analyzed.Results The Cmax and AUC0-t were significantly... |
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| Keywords: | Cepharanthine Fexofenadine HPLC Pharmacokinetics |
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