供肾穿刺活检在亲属活体肾移植中的应用及边缘供肾对受者预后的影响

目的 分析供肾穿刺活榆在亲属活体肾移植中对供肾质量的诊断价值及边缘供肾对亲属活体肾移植受者早期预后的影响.方法 2004年2月至2008年7月142例亲属活体肾移植患者,按照供体年龄和供肾情况分为边缘供者组(51例)和非边缘供者组(91例).并对49例亲属活体供肾行细针穿刺活检术.分析2组受者的术后血肌酐(Scr)变...

Applications of renal biopsy in living-related kidney transplantation and the influences of the marginal donor on the recipient prognosis

Objective To analyze diagnostic value of renal biopsy in living-related kidney transplantation and the influence of kidneys from marginal donors on the early prognosis of recipients. Methods According to donors age and risks of donors, 142 living-related kidney transplant recipients from February 2004 to July 2008 were divided into marginal donor group (51 cases) and non-marginal donor group (91 cases). Renal biopsy was performed on 49 kidneys Postsurgical serum creatinine (Scr), the lowest Scr and post-transplant complications were analyzed between the two groups. Results Pathological changes were detected in 13 cases. The Scr at 4 weeks, 12 weeks, 6 months post-transplant and the lowest level of Scr in marginal donor group were higher than those in non-marginal donor group (all P<0.05). There were no significant differences of Scr levels at 12 months, 24 months, 36 months post-transplant, the time required to return to the lowest Scr, and post-transplant complications between two groups (all P>0.05). Conclusions The early clinical efficacy of the marginal donor is ideal, but the baseline of Scr of recipients is higher than that of recipients with kidneys from non-marginal donors. Renal biopsy has an important diagnostic and therapeutic value for both donors and recipients.