结直肠癌组织中KLF6蛋白的表达及其与血清癌胚抗原的相关性

目的：探讨KLF6蛋白在结直肠癌组织中的表达及其与血清癌胚抗原的相关性。方法：应用免疫组化SP法检测KLF6蛋白在结直肠癌、结直肠腺瘤及正常结直肠组织中的表达，分析KLF6蛋白与结直肠癌各种临床病理参数的关系。用酶联免疫吸附试验(ELISA法)检测结直肠癌患者血清CEA水平。结果：KLF6蛋白从正常结直肠组织、结直肠腺瘤到结直肠癌组织中表达逐渐下调（85.7%，76.5%，43.6%），三者比较差异有统计学意义（X2=25.20，P<0.01）；KLF6蛋白表达水平与组织学类型无关（X2=0.13，P>0.05），与分化程度（X2=4.04）、淋巴结转移（X2=6.79）、TNM分期（X2=6.16）有关（P<0.05）；CEA水平与肿瘤分期相关，与肿瘤细胞分化程度并不相关；KL6表达与患者血清CEA水平无明显相关(P>0.05)。结论：KLF6表达下降，可能参与了结直肠癌的发生发展；KLF6基因可能是结直肠癌的一个重要抑癌基因并可能参与结直肠癌细胞凋亡的调节。CEA可作为结直肠癌恶性程度的一个监测指标，长期的随访有助于评价手术疗效、是否转移和监测复发。

Expression of KLF-6 protein in colorectal cancer and its correlation with serum CEA

Objective To study the expression of KLF6 protein in colorectal cancer(CRC) and its correlation with serum CEA level. Methods The expression of KLF6 protein in colorectal cancer,colorectal adenoma,and normal colorectal tissues was detected by immunohistochemistry.Serum CEA level in patients with colorectal cancer was measured by ELISA. Results The expression of KLF6 protein in normal colorectal tissues,colorectal adenoma and colorectal cancer were 85.7%,76.5% and 43.6%,respectively,with significant differen...