The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease |
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| Authors: | Hiromistu Ban Akira Andoh Hirotsugu Imaeda Ayako Kobori Shigeki Bamba Tomoyuki Tsujikawa Masaya Sasaki Yasuharu Saito Yoshihide Fujiyama |
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| Affiliation: | (1) Department of Medicine, Shiga University of Medical Science, Otsu, Japan;(2) Division of Mucosal Immunology, Graduate School of Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu 520-2192, Japan; |
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| Abstract: | Background Multidrug resistance protein 4 (MRP4) functions as an efflux pump of nucleoside monophosphate analogs, such as 6-mercaptopurine (6-MP) and 6-thioguanine nucleotide (6-TGN). A single-nucleotide polymorphism in human MRP4 (rs3765534) dramatically reduces MRP4 function and results in the intracellular accumulation of 6-TGN. In this study, we investigated the association between MRP4 G2269A polymorphism and thiopurine sensitivity in Japanese IBD patients. |
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