伊曲康唑巩固疗法降低花斑癣复发率的临床研究

目的:探讨一种能够降低花斑癣复发率的有效治疗方案。方法:将初诊的花斑癣患者按就诊时间分为两组,均口服伊曲康唑0.2g,每日1次,连续服药7d。7d后对照组停药观察,试验组则继续服用伊曲康唑,每月口服0.2g1次,共6个月。两组患者皆每月复诊1次,共6次。结果:试验组99例患者复发率为1.01%,治愈率为85.86%。对照组95例患者复发率为17.89%,治愈率为64.21%。经卡方检验两组患者的复发率及治愈率相比,差异均有极显著性(χ2=16.4195,P=0.0001和χ2=12.2013,P=0.0005)。结论:巩固治疗方案能在近期内降低花斑癣复发率,同时提高花斑癣的治愈率。

A comparative clinical study of the consolidation treatment of itraconazole in pityriasis versicolor

Objective: To investigate an effective treatment plan to reduce the recurrence rate of pityriasis versicolor. Methods: The patients with pityriasis versicolor were allocated to two groups at random. All patients orally took itraconazole 0.2 g once daily for 7 days. As prophylactic treatment 0.2 g itraconazole was continually given once a month for 6 months in the test group. As control nothing was continually used. The therapeutic effects were evaluated once a month for 6 months. Results: The clinical recurrence rate and cure rate in the test group were 1.01% and 85.86% respectively, while it were 17.89% and 64.21% in control group. There were statistically significant differences in above-mentioned two rates between the two groups (P = 0.000 1, P = 0.000 5). Conclusion: The consolidation treatment in pityriasis versicolor can reduce the recurrence rate and increase the cure rate.