重度创伤患者细胞因子变化及临床意义

目的探讨重度创伤患者细胞因子的变化及临床意义。方法采用ELISA法检测48例重度创伤患者入院时、入院后第12h,3、7、14d（ISS≥10）血中IL-4（IL-4）、IL-6（IL-6）及肿瘤坏死因子-α（TNF-α）水平变化,并与正常健康人进行比较。结果多发性创伤后血中IL-4、IL-6及TNF-α水平早期即显著高于正常对照组（P〈0.05）,于伤后第3天后达到高峰（P〈0.01）,随后逐渐降低,于伤后2周仍显著高于正常。多发性创伤IL-4、IL-6及TNF-α水平升高幅度与ISS评分呈显著正相关。结论动态观察多发性创伤患者细胞因子活性的变化有助于病情的评估及预后判断。

Changes of cytokine index in patients with severe trauma and its clinical significance

Objective To study the changes of cytokines in patients with severe trauma and its clinical significance. Methods The concentration of the IL-4,IL-6 and TNF-α was measured by enzyme linked immunosorbent assay（ELISA） in 48 patients with severe trauma at admission and 12 hours, 3,7 and 14 days, and were compared with those in the healthy control group simultaneously. Results The serum IL-4, IL-6 and TNF-α in patients with severe trauma were shown to be significantly higher than those in the control group. The IL-4, IL-6 and TNF-α increased at the early stage and reached the peak at 3 days and subsequently decreased gradually in 2 weeks after trauma. The ISS scores of patients were positively correlated with the peaks of IL-4, IL-6 and TNF-α Conclusion Investigating the changes of cytokines in patients with severe trauma would contribute to evaluate the patient＇ s condition and judge the prognosis of this disease.