乳腺癌X线征象与血管内皮生长因子C和雌激素受体表达的关系

目的 探讨乳腺癌X线表现与血管内皮生长因子C(VEGF-C)、雌激素受体(ER)表达的关系.方法 75例经手术病理证实乳腺癌标本运用免疫组织化学方法检测VEGF-C、ER表达情况,分析其与术前钼靶X线征象的关系.结果 VEGF-C与X线上肿瘤的大小、钙化、血管增粗有关(P＜0.05),与肿瘤毛刺征、皮肤增厚、乳头内陷等征象无明显相关(P＞0.05).ER与肿瘤的毛刺征相关(P＜0.05),与肿瘤的大小、毛刺征、血管增粗、皮肤增厚、乳头内陷等征象无相关性(P＞0.05).ER呈阳性乳腺癌组织中VEGF-C表达较阴性组表达低,但两者差异无统计学意义(P＞0.05).结论 乳腺癌钼靶X线部分征象与VEGF-C和ER表达密切相关,通过部分征象,可推测乳腺癌的生物学行为,为临床上早期诊断、判断预后提供依据.

Correlation between mammographic signs and expression of VEGF-C and ER in breast cancer

Objective To explore the relationship between mammo- graphic signs and the expression of VEGF-C and ER in breast cancer.Methods A total of 75 cases of breast cancer confirmed surgically and pathologically were enrolled in this study.The expression of VEGF-C and ER was detected by using immunohistochemical technique.The relationship between preoperative mammographic signs and the expression of VEGF-C and ER was analyzed.Results The expression of VEGF-C was related to the tumor size,enlarged vessels and cluster of calcification ( P＜0.05 ),but not to spicule signs,crassus skin and retracted nipple ( P＞0.05 ).The expression of ER was related to the spicule signs ( P＜0.05 ),but not to tumor size,cluster of calcification,enlarged vessels,crassus skin and retracted nipple ( P＞0.05 ).The expression of VEGF-C in group of ER-positive expression was lower than the group of ER-negative expression,but there was no significant difference between them ( P＞0.05 ).Conclusion The mammographic signs of breast cancer are closely related to the expression of VEGF-C and ER.This mammographie signs can predict biological behaviors of breast cancer and may be evidence for early diagnosis and prognostic evaluation of breast cancer.