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Antihyperglycaemic activity of Ceriops tagal in normoglycaemic and streptozotocin-induced diabetic rats |
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| Authors: | Priti Tiwari Akhilesh Kumar Tamrakar Rehan Ahmad Mahendra Nath Srivastava Rajesh Kumar Vijai Lakshmi Arvind Kumar Srivastava |
| Affiliation: | 1. Division of Biochemistry, Central Drug Research Institute, Lucknow, 226001, India 2. Division of Botany, Central Drug Research Institute, Lucknow, 226001, India 3. Divisions of Medicinal Process Chemistry, Central Drug Research Institute, Lucknow, 226001, India |
| Abstract: | Antihyperglycaemic effect of the crude extract (1) and four fractions (2, 3, 4, and 5) of Ceriops tagal (Perr.) C.B. Rob. (Rhizophoraceae) were evaluated in normal healthy sucrose-loaded and STZ-induced diabetic rats. The crude extract improved the glucose tolerance of the sucrose-loaded rats significantly (p < 0.05) with 33.2% activity, while in STZ-induced diabetic rats the extract caused a fall of 10.9% in hyperglycaemia. All of the four isolated fractions improved the glucose tolerance of normal rats post sucrose load, albeit to varying degree. Fraction 4 exerted the strongest effect of 37.2% (p < 0.05) in sucrose-loaded rats while in STZ-induced diabetic rats it caused a fall of 17% (p < 0.05) in hyperglycaemia. The fasting blood glucose levels of STZ-induced diabetic rats were normalized and the glucose tolerance of these animals was significantly improved after 20 days of daily oral administration of fraction 4 at a 100 mg/kg dose. |
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