Cerebrovascular pulsatility in patients with sleep-disordered breathing |
| |
Authors: | Alberto R Ramos Digna Cabral David J Lee Ralph L Sacco Tatjana Rundek |
| |
Institution: | 1. Department of Neurology, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite 1350, Miami, FL, 33136, USA 2. Department of Epidemiology and Public Health, University of Miami, Miami, FL, USA 3. Department of Human Genetics, University of Miami, Miami, FL, USA
|
| |
Abstract: | Purpose The aim of our study is to determine the association between the pulsatility index (PI), a surrogate of cerebral small vessel disease and sleep-disordered breathing (SDB). Methods We conducted a transcranial Doppler ultrasound (TCD) study of 19 consecutive patients free of stroke and cardiovascular disease, referred for the evaluation of SDB. TCD was performed by a certified technologist. Subsequent polysomnography was performed according to the practice parameters of the American Academy of Sleep Medicine. We evaluated the association between the apnea–hypopnea index (AHI), the oxygen nadir, the blood flow velocities, and the Gosling PI, for the middle cerebral artery. We performed Spearman's rank correlation and nonparametric regression to evaluate the relationship between AHI, oxygen levels, and the PI. Results Median age was 48 years (range 37–83), with 52 % male sex (n?=?10), and median BMI of 29.9 (range 25–40.4). The median AHI was 16.4 (0.2–69). The median PI was 0.97 (0.72–1.89) cm/s. The PI correlated with the AHI (rho?=?0.44; p?=?0.004) and with age (rho?=?0.57; p?=?0.001). Nonparametric regression adjusting for age showed a positive association between the AHI and the PI (standardized estimate?=?0.88; p?=?0.002). There was no relation between the oxygen nadir and the PI. Conclusion We observed increased PI in patients with SDB during wakefulness. The PI could potentially be an estimate of cerebral small vessel disease in patients with SDB and hence allow evaluating cerebral hemodynamics during wakefulness with a clinically relevant device. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|